Current evidence suggests that tirzepatide does not meaningfully transfer into breast milk. The larger concern during breastfeeding is not drug exposure, but reduced calorie and nutrient intake due to appetite suppression. If you have just delivered and are exclusively breastfeeding, starting a medication that significantly reduces appetite is usually not ideal — primarily for nutritional reasons rather than concerns about medication passing into milk. In contrast, if you are breastfeeding a toddler only a few times per day for comfort, overall risk is likely minimal because breast milk is no longer the child’s sole source of nutrition.