Cocaine is a local anesthetic as well as a CNS stimulant. It can either be inhaled or in the case of crack, smoked. Use of cocaine during pregnancy is associated with premature birth, IUGR, placental abruption, and low birth weight. 

Although malaria is not endemic to the US, many US travelers are affected by this illness when traveling to places such as sub-Saharan Africa and Central and South America. Malaria has been shown to cause maternal anemia, premature birth, and low birth weight in affected infants.

Rubella, also known as the German Measles, is a viral illness. If the infection occurs during pregnancy, it can result in what is known as congenital rubella syndrome (CRS). Women in their first trimester of pregnancy are at greatest risk of developing a viremia and congenital birth defects from this illness. Congenital rubella syndrome is characterized by abnormalities including heart defects, deafness, and cataracts. (1) Other common abnormalities seen in the newborn are thrombocytopenia and encephalitis.