Lexapro and Domperidone

[akennard]

Hi,

I've seen that fluoxetine and citalopram are not advised while taking domperidone, but have not seen anything about escitalopram (Lexapro), which is generally considered a "cleaner" drug with less interaction than citalopram. I started domperidone (80 mg/day) for low milk supply, likely secondary to hemorrhage, surgical birth, retained placenta, and possibly related to central hypothyroidism (low TSH, low T3/T4). I took Lexapro prior to pregnancy for OCD/depression but did not take it during pregnancy to avoid infant risk. I think I have some postpartum depression which is largely related to the nursing issues- I desperately wanted to breastfeed exclusively.
Thoughts on lexapro with domperidone and dosing?

Thanks,
Anne

[admin]

Anne:

Some of our sources list a major drug interaction with Lexapro and domperidone. I'd suggest caution as many drug reduce the metabolism of Domperidone and apparently Lexapro is one of them. I'd also suggest a reduction in dosage to 60 mg per day or less.

Tom Hale Ph.d