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Drugs given IV versus orally, and morphine

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  • Drugs given IV versus orally, and morphine


  • #2
    you are right

    you are right

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    • #3
      So, even though the general rule is that more of a drug given IV, as compared to orally, reaches breastmilk, this doesn't necessarily mean that more of it is available to the baby, as many drugs that are given IV are often not absorbed well orally. Right?

      So, with the case of morphine, would oral or IV morphine given to a breastfeeding mother have more of an effect on her baby through her breastmilk?

      Thanks

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      • #4
        Prince:

        Regardless of the route of delivery to the mom, the amount of morphine in milk is moderate to low. AND the amount in milk must first pass the babies portal circulation and then pass through the liver. 75% of this dose in milk, is sequestered and metabolized in the liver BEFORE absorption into the plasma compartment of the baby. This is why we generally consider morphine an ideal analgesic in breastfeeding mothers...assuming the dose is not too high.

        That said, 75% of a super high dose, is still high. So moms that receive very high doses of morphine, or moms that abuse drugs and use high doses of heroin, produce a higher absorption in the infant and greater risk to the infant.



        Tom Hale Ph.D.

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        • #5
          Thank you.

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          • #6
            Yes in my point of view it is right"even though the general rule is that more of a drug given IV, as compared to orally, reaches breastmilk, this doesn't necessarily mean that more of it is available to the baby, as many drugs that are given IV are often not absorbed well orally."

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