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Zoloft and Buspar

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  • #1

    Zoloft and Buspar

    I'm currently taking 100mg of Zoloft and my Dr. wants me to add 10mg of Buspar up to 3x/day. Are these safe to take together? I'm exclusively nursing a 5 month old.
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  • #2
    Kate209,

    Zoloft (sertraline) is rated an L1-extensive data-compatible. Only 0.4-2.2 % of your dose transfers into breastmilk. Sertraline has been extensively studied in many breastfeeding mothers. The data is consistent that levels in milk are quite low, sertraline is a preferred antidepressant in lactation. Monitor your infant for Sedation or irritability, not waking to feed/poor feeding and weight gain.


    Buspar (busperirone) is rated an L3-no data-probably compatible. Currently there are no data regarding buspirone excretion into human milk; several properties of this medication suggest it has difficulty-entering breastmilk like high protein binding, short half-life, large volume of distribution, low oral bioavailability, and minimally active metabolites. Monitor your infant for behavioral changes, feeding problems, appropriate weight gain. This medication has a short half-life, if you can wait 2-3 hours after a dose half the medication is out of your system.

    According to Micromedix no drug to drug interactions.

    Sandra Lovato R.N.
    InfantRisk Center
    806-352-2519

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