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  • Noritate cream

    is noritate cream used for Rosacea safe during pregnancy?? It is used once daily.

  • #2
    Chiredhead:

    The absorption of metronidazole from this cream is quite low, < 1%. . Below is from the package insert. Metronidazole is not considered teratogenic.

    Tom Hale Ph.d.



    Package insert:

    When a one gram dose of NORITATE cream, 1%, was applied in a single application to the face of 16 healthy volunteers, low concentrations of metronidazole were detected in the plasma of 7 of the volunteers. The mean ± SD Cmax of metronidazole was 27.6 ± 7.3 ng/mL, which is about 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (Tmax) in the volunteers with detectable metronidazole was 8–12 hours after topical application.

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