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Breo inhaler

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  • #1

    Breo inhaler

    Is breo inhaler safe to use during pregnancy? Is advair a better choice during pregnancy? Thank you!
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  • #2
    Chiredhead,

    Advair is a combination of Fluticasone and Salmeterol it is rated a P3 – Unknown, risk to the fetus cannot be ruled out. Studies have shown that inhaled corticosteroids and beta agonists do not increase the risk of congenital malformations if used during pregnancy. [2] In a 2006 study published in the Australian and New Zealand Journal of Obstetrics and Gynaecology , they found that women who used combination therapy of anti-inflammatory agent with a bronchodilator, had a higher incidence of low birthweight infants compared to the control.[3] However, studies on inhaled corticosteroids alone have not found an increase risk of prematurity, low birth weight, or pregnancy induced high blood pressure. [2] Due to the adverse outcomes associated with uncontrolled asthma during pregnancy, the benefits of controller medication, when necessary, outweigh any probable risks[4].

    Breo is not in our database. It is a combination of Fluticasone and Vilanterol. According to Dailymed it would be a category C in pregnancy. There are no adequate and well-controlled studies with BREO in pregnant women. Corticosteroids and beta2-agonists have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels.There is however no evidence of teratogenic interactions between fluticasone and vilanterol in rat studies at approximately 5 and 40 times, respectively, the maximum recommended human daily inhalation dose in adults on a mcg/m2 basis with fluticasone and vilanterol, alone or in combination, up to approximately 95 mcg/kg/day.

    1.##Kastrup E. Drug Facts and Comparisons: Wolters Kluwer Health; 2010.
    2.##Rahimi R, Nikfar S, Abdollahi M. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol. Aug 2006;25(8):447-452.
    3.##Clifton VL, Rennie N, Murphy VE. Effect of inhaled glucocorticoid treatment on placental 11beta-hydroxysteroid dehydrogenase type 2 activity and neonatal birthweight in pregnancies complicated by asthma. Aust N Z J Obstet Gynaecol. Apr 2006;46(2):136-140.
    4.##Gluck JC, Gluck PA. Asthma controller therapy during pregnancy. Am J Obstet Gynecol. Feb 2005;192(2):369-380.

    [url]https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96428df1-ea05-431a-98d3-1ec2c4b63878[/url]

    Sandra Lovato R.N.
    InfantRisk Center
    806-352-2519

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