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methimazole

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  • #1

    methimazole

    Hi,
    I currently have a patient who is 25 weeks pregnant with hyperthyroid and taking Methimazole. I know it is safe for breastfeeding but wondering if it is safe during pregnancy.
    Thank you,
    Lori Lindsey RN IBCLC
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  • #2
    Lorirn:

    Methimazole is quite hazardous for a fetus and it is not recommended. Methimazole readily crosses the placental membranes and can induce goiter and even cretinism in the developing fetus. In addition, rare instances of congenital defects: aplasia cutis, as manifested by scalp defects; esophageal atresia with tracheoesophageal fistula; and choanal atresia with absent/hypoplastic nipples, have occurred in infants born to mothers who received methimazole during pregnancy.

    In severe hyperthyroidism in pregnant women, Propylthiouracil is the recommended drug.

    Tom Hale Ph.d.

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