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Ambien (Zolpidem) during pregnancy

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  • Ambien (Zolpidem) during pregnancy

    Is 5mg zolpidem a few times a week compatible with pregnancy?

    currently 18wks pregnant

  • #2
    Jackie1234,

    "There were no detectable congenital anomalies in 11 births exposed to zolpidem during the first trimester of gestation.[1] There is one case of an infant whose mother took zolpidem in combination with fluvoxamine and meprobamate in the first five weeks of pregnancy; The infant was born with hydrocephaly, right diaphragmatic hernia, and agenesis of the corpus callosum.[2] However, no conclusions can be made on the basis of this single report. [4] One case reported transplacental transfer of zolpidem.[3] A 30-year-old woman who had a history of zolpidem abuse delivered spontaneously at 38 weeks of gestation. It was estimated to be at least 1000 mg over at least 1 month; however, the total fetal exposure to zolpidem was unknown. In the blood cord, the concentration of zolpidem was 41 ng/mL. The neonate was active and alert, and no withdrawal symptoms were noted despite the presence of zolpidem in the cord blood sample.[3] There are no additional data available on the behavior of neonates born to women on zolpidem.[4] However, experience with other sedative-hypnotics suggest that flaccidity or withdrawal symptoms may occur.[4] Furthermore, neonates born to women on benzodiazepines may show temperature instability; whether such effects will occur after zolpidem exposure is unknown. [4]" (Medications and Mothers' Milk database, Dr Thomas Hale PhD).



    1.## Wilton LV, Pearce GL, Martin RM et al: The outcomes of pregnancy women exposed to newly marketed drugs in general practice n England. Br J Obstet Gynaecol 105:882-889, 1998.
    2.## McElhatton PR, Garbis HM, Elefant E et al: The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepres ants. A collaborative study of the European Network of Teratology Information Services (ENTIS). Reprod Toxicol 10:285-294, 199 .
    3.## Askew JP: Zolpidem addiction in a pregnant woman with a history of second-trimester bleeding. Pharmacotherapy 2007; 27:306- .
    4.##The REPROTOX® System. Georgetown University Medical Center and Reproductive Toxicology Center, Columbia Hospital for Women Medical Center, Washington, D.C. (electronic version). Thomson Reuters, Greenwood Village, Colorado, USA. Available at: [url]http://csi.micromedex.com[/url] (May/28/2010).

    Sandra Lovato R.N.
    InfantRisk Center

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