100 mg of setraline & 2 mg of lorazapram

[Msrara]

Hi,
I am wanting to have another child and I am currently taking 100 mg of setraline and 2 mg of lorazapram. Should I wean off the lorazapam first? What dosage is safe in pregnancy with setraline?
Thank you!

[admin-james]

Hi, thanks for your post.

Millions of babies have been exposed to Sertraline during pregnancy at dosages up to 200mg/day, and the outcome is normal. We occasionally see a mild withdrawal reaction in less than 30 percent of infants after delivery, but this is without complication and goes away in 1-2 days.

Lorazepam and other medications in the same class have been liked to a low rate of birth defects in the first trimester. I am unable to find studies that comment on safety in the second trimester. Use in the third trimester has been associated with a withdrawal syndrome in the infant. In other words, lorazepam should not be your first choice of anxiety medication while pregnant, but it may be reasonable to start back on a low dose around week 30.

Please call us at the InfantRisk Center if this has not completely answered your question.*(806)352-2519

James Abbey, MD
and
Thomas W. Hale, Ph.D.