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I have permission to post. I am caring for a newly delivered mother who has congenital angioedema. She has takenb danazol 100mg OD for this for many years, but stopped in order to concieve. She is currently having IV medication, and has had this for 2 years. As her Hickman line will need to come out in a couple of weeks, she will need to restart the Danazol. At the moment she is berastfeeding, and is really keen to continue. Obviously this is a L5 medication - is this becasue of the possible impact on prolactin levels, or becasue of harm to the baby through milk transfer? Kind regards
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Dear cscmadwife,
Dr Hale states that danazol suppresses the pituitary-ovarian axis by inhibiting ovarian steroidogenesis resulting in decreased secretion of estradiol and may increase androgens. Danazol is believed to reduce plasma prolactin levels in individuals. Due to its effect on pituitary hormones and its androgenic effects, it may reduce the rate of breastmilk production although this has not been documented. No data on its transfer to human milk are available.
Sincerely,
Cindy Pride, MSN, CPNP
TTUHSC InfantRisk Center
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