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Midrin (Isometheptene, Dichloralphenazone, and Acetaminophen)

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  • #1

    Midrin (Isometheptene, Dichloralphenazone, and Acetaminophen)

    Prior to my pregnancy I was taking Midrin for tension headaches and migraines. I did not take Midrin while pregnant or while breastfeeding my daughter for the past 6 months. I was wondering if it was safe to take while breastfeeding if I have the need to in the future? I know the acetaminophen contained in it is not a problem, but what of the other two ingredients?
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  • #2
    Dear Jambrose,

    We have no data on how much Midrin transfers into breastmilk. Due to its size and molecular composition, it is likely to attain low to moderate levels in breastmilk. There are several effective medications for migraines that we have breastfeeding data on. You may want to talk with your physician about sumatriptan, amitriptyline or propranolol as alternatives. Acetaminophen and ibuprofen are over the counter medications that are also effective for headaches that are compatible with breastfeeding. Only 0.1 percent to 0.7 percent of your ibuprofen dose enters breastmilk. Acetaminophen has a larger amount that enters breastmilk, but because the drug is also given to young infants, it is still compatible with breastfeeding. You should not exceed 3000 mg of acetaminophen in 24 hours to prevent liver toxicity. Hope this information helps.

    Sincerely,
    Cindy Pride, MSN, CPNP
    TTUHSC InfantRisk Center

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