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Are there any unpublished data on Semaglutide and breast milk transmission? Thanks!
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Molecular weight = 4113
Semaglutide is a human GLP-1 receptor agonist (or GLP-1 analog). Semaglutide reduces blood glucose whereby it stimulates insulin secretion and lowers glucagon secretion, both in a glucose-dependent manner. Thus, when blood glucose is high, insulin secretion is stimulated, and glucagon secretion is inhibited. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying in the early postprandial phase. This product is large in molecular weight, and is not absorbed orally in the human. Due to its large molecular weight it is unlikely to enter milk or be orally absorbed by the infant. However, caution is recommended until we have more data on milk levels following the use of this hypoglycemic agent.
And no, there is nothing published about its entry into human milk.
Tom Hale Ph.D. -
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