Labetalol and Breastfeeding

[sweetpea2700]

Hi Dr. Hale & Team,

I was curious what you would recommend for a Mom on Labetalol who is concerned about breastfeeding? She is pumping and dumping until her blood pressure stabilizes. Would it be advised to breastfeed 2 hours after taking Labetalol or ideally 3 hours as the half-life is 5.5 hours? The baby is now on formula. Any suggestions for breastfeeding and taking this medication?

Thanks so much!

Sincerely,

Kaley

[cpride]

Dear Kaley,

Labetalol is a selective beta blocker with moderate lipid solubility that is used as an antihypertensive and for treating angina. In one study levels in milk were extremely low (0.2 to 0.6 percent of maternal dose), therefore, only small amounts are secreted into human milk. The time the medication would be highest in breastmilk would be one to two hours after each dose so avoid breastfeeding during those times, if possible. Observe the infant for lethargy and poor feeding. Labetalol is probably compatible with breastfeeding.

Sincerely,
Cindy Pride, MSN, CPNP
TTUHSC InfantRisk Center