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Methyldopa and Amlodipine in Breastfeeding

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  • Methyldopa and Amlodipine in Breastfeeding

    Hi - I am 9 weeks postpartum and have been prescribed 5mg of Amlodipine (once daily) and 250mg Methyldopa (2x daily) for the treatment of chronic hypertension. I have done extensive research but find conflicting information on the safety of the medications with lactation. It appears that Methylopa is found to be "safer" due to nominal amounts that are excreted into breastmilk. Re: Amlodipine, the findings are less clear and confident. I have asked my OB, Hypertension specialist and PCP about Amlodipine and all assure me it's "probably safe." Pediatrician relies on prescribing docs and Lactmed book. I would love a more thorough explanation of safety of both drugs as it pertains to breastfeeding. I absolutely want to continue to breastfeed but have major reservations as I am concerned about potential harm to my baby. What could those effects be and are they serious? THANK YOU!

  • #2

    Amlodipine (norvasc), is rated an L3-no data-probably compatible. We do not know how much transfers into human milk, but b[COLOR=#333333][FONT=lucida grande]ecause most calcium channel blockers (CCB) readily transfer into milk, we should assume the same for this drug so use it with some caution. Monitor the infant for weakness, drowsiness, lethargy, pallor, poor feeding and weight gain, if the infant is not symptomatic this medication should be ok to use.

    Methyldopa is rated an L2-limited data-probably compatible. The amount transferred into breast milk is 0.1-0.4% of your dose. Methyldopa is probably safe to use during breastfeeding. The levels of methyldopa transferred into milk are minimal. Monitor the infant for weakness, drowsiness, lethargy, pallor, poor feeding and weight gain.

    I hope this helps. If you have any other questions please call the InfantRisk Center at 806-352-2519. Thanks,

    Sandra Lovato R.N.
    InfantRisk Center[/FONT][/COLOR]