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Sildenafil in breastfeeding

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  • Sildenafil in breastfeeding

    We have a mother on sildenafil 50 mg bid and frusemide 20 mg tid for pulmonary hypertension. Is there any new data regarding safety of sildenafil in lactating patients?

    Thanks,
    Ghada Al Tajir
    Al Qassimi Hospital
    United Arab Emirates

  • #2
    Ghada:


    Sildenafil is a phosphodiesterase type 5 (PDE-5) inhibitor. It has vaso-dilating and smooth muscle relaxing properties. It is used in the treatment of pulmonary hypertension and in erectile dysfunction in men. No data are available on the transfer of sildenafil into human milk, but due to its pharmacokinetic parameters, it is unlikely that significant transfer will occur. However, caution is recommended in breastfeeding mothers. Oral sildenafil has been used successfully in infants for the management of pulmonary hypertension. No untoward effects were reported in these infants.

    Finally, observe infant for hypotension and prolonged erections.

    Regards

    Tom Hale Ph.D.

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