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I am not finding much information in regards to the safety of Pristiq in breastfeeding mothers. I've read it is similar to Effexor and that there are better choices. Any advice would be much appreciated. Thank you
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cbrniclc:
Venlafaxine is metabolized to desvenlafaxine (Pristiq). So I'm sure the data for venlafaxine will be similar to the data for Pristique(desvenlafaxine). See below. Less than 10% of the dose of venlafaxine reaches the infant.
In a study of 6 women receiving an average of 244 mg/day venlafaxine, the mean maximum concentration of desvenlafaxine in milk was 796 ng/mL. Desvenlafaxine was detected in the plasma of 4 of the infant ranging from 3 to 38 ng/mL. All the infants were healthy and unaffected. The M/P ratio for venlafaxine and desvenlafaxine were 2.5 and 2.7 respectively.
In a group of 13 women who consumed from 37.5 to 300 mg/day (mean=194.3 mg/d) of venlafaxine, levels of desvenlafaxine in milk ranged from 318 to 1912.7 ng/mL with a mean of 919 ng/mL. The RID for desvenlafaxine using the highest levels reported (Cmax) ranged from 6.8% to 9.3%. This data clearly suggests that desvenlafaxine enters milk at a higher rate than the parent drug, venlafaxine. The highest desvenlafaxine levels occurred 8 hours after maternal ingestion.
Regards
Tom Hale PH.D.
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