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  • Cymbalta research?

    Looking for any information available on Cymbalta and breastfeeding mothers. Patient dose 30mg 1x/day. Baby is 6 weeks old and weighs 15lbs.

    Mother was taken off same dose when she found out she was pregnant and does not want to try a different mediaction. Her dr has agreed but asked that I provide follow up info and any studies I can find.

    Thanks!

  • #2
    LCmomof3, thanks for posting,

    Cymbalta is rated an L3-limited data-probably compatible. New data suggest that the milk/plasma ratio is low, and the RID (relative infant dose) is low as well. Only 0.1-1.1% of moms dose transfers into breast milk. This is usually too low to have clinical effects on an infant. We still advise to monitor the infant for sedation or irritability, not waking to feed/poor feeding and weight gain.

    I hope this helps. If you have any other questions please call the InfantRisk Center at 806-352-2519. Thanks,

    Sandra Lovato R.N.
    InfantRisk Center

    Comment


    • #3
      Sandra thanks for the quick response. Do you possibly have a link to new research? I found something along those same lines a few months back when mom came to me when pregnant but now I can't find it!

      Comment


      • #4
        LCmomof3,


        These are Dr Hales references out of his book Medications and Mothers Milk 2014

        1.##Pharmaceutical manufacturer prescribing information,2005.
        2.##Lobo ED, Loghin C, Knadler MP et al. Pharmacokinetics of duloxetine in breast milk and plasma of healthy postpartum women. Clin Pharmacokinet. 2008;47:103-109.
        3.##Briggs GG, Ambrose PJ, Ilett KF, Hackett LP, Nageotte MP, Padilla G. Use of duloxetine in pregnancy and lactation. Ann Pharmacother. Nov 2009;43(11):1898-1902.
        4.##Boyce PM, Hackett LP, Ilett KF. Duloxetine transfer across the placenta duringpregnancy and into milk during lactation. Arch Womens Ment Health. 2011Apr;14(2):169-72.


        This is Dailymeds website that gives some information under "specific populations" for breastfeeding.

        http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2f7d4d67-10c1-4bf4-a7f2-c185fbad64ba


        Here are some articles from Pubmed.

        http://www.ncbi.nlm.nih.gov/pubmed/25551238
        http://www.ncbi.nlm.nih.gov/pubmed/21359876

        Sandra Lovato R.N.
        InfantRisk Center

        Comment

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