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Chemotherapeutic agents targeting lactocytes?

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  • Chemotherapeutic agents targeting lactocytes?

    I've been on ABVD chemotherapy for Hodgkin's lymphoma for the past 3 months, hoping to start breastfeeding in between treatments, understanding I have to wait 10 days for these drugs to clear my system. But I've been having a lot of trouble with my milk supply. I'm wondering if my chemo drugs are affecting my ability to produce milk? Would ABVD chemotherapy kill off lactocytes?

  • #2
    Anneke,

    I'm sorry we just do not know if the chemo agents could decrease milk supply, we have had a few calls where moms on chemo have had low supply.

    Sandra Lovato R.N.
    InfantRisk Center
    806-352-2519

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    • #3
      Any information on whether galactogogues like domperidone are safe with chemo or would help with low milk supply in this situation? Thanks!

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      • #4
        Anneke:

        Galactagogues like domperidone are great IF you have low prolactin levels. I'd have your doctor draw a blood sample 2 hours after breastfeeding, and measure prolactin levels. If they are < 50 ng/mL, then domperidone would work great.

        As domperidone may alter your heart beat, have your doctor do an EKG first and keep the dose 30-60 mg per day. (Evaluate for Prolonged QT interval)

        Withhold periods for these drugs is :

        Doxorubicin : 7-10 minimum
        Bleomycin : 24 hours minimum
        Vinblastine: 10 days minimum
        Dacarbazine : 48 hours minimum



        Tom Hale Ph.D.

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