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Would you please comment on the recent letter in annals of oncology Volume 23 No. 2, pages 543-544, regarding the absence of 5-FU in the milk of a woman being treated for rectal carcinoma, despite normal plasma pharmacokinetics. i notice it does not discuss the metabolites of 5-FU. Would you expect the transfer to be similar? Would this information, although clearly based on only one woman, make breastfeeding with careful monitoring of the infant more reasonable?
My sister, recently diagnosed with a gastric adenocarcinoma, will begin chemotherapy with 5-FU and leucovorin in the next few weeks.
She is nursing a nearly 5 month old infant who, to date has absolutely refused all alternative sources of nutrition, including pumped breast milk. Out of desperation he was wet nursed by family and friends during her surgery (this would be more challenging long term), so she is anxious to carefully consider all available information before making a decision to wean.
Are assays of this type readily available at a university center?
Thanks for your thoughts. Family physician, Vancouver
My sister, recently diagnosed with a gastric adenocarcinoma, will begin chemotherapy with 5-FU and leucovorin in the next few weeks.
She is nursing a nearly 5 month old infant who, to date has absolutely refused all alternative sources of nutrition, including pumped breast milk. Out of desperation he was wet nursed by family and friends during her surgery (this would be more challenging long term), so she is anxious to carefully consider all available information before making a decision to wean.
Are assays of this type readily available at a university center?
Thanks for your thoughts. Family physician, Vancouver
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