Orphenadrine citrate and breastfeeding

[enruf]

Hi,
I couldn't find entry about this drug (a muscle relaxant), used here in the U.A.E. (trade name: Muscadol) at the dose of 35 mg, in combination with paracetamol (acetaminophen) 450 mg. This is for a mother who delivered a few days ago, who needs analgesia (she has been suffereing from severe denervation pain (back ache) during the last 2 weeks of pregnancy). The hospital team wants to give her this drug, but she is worried.
Thanks for the help.

[Sandra]

Enruf,

Orphenadrine citrate (Muscadol) is rated an L3-no data-probably compatible. [COLOR=#333333][FONT=lucida grande]No data are available on its secretion into breastmilk. Until more is known about the transfer of this drug in to human milk, use with caution in breastfeeding mothers. Observe for sedation, agitation, dizziness, tremor, dry mouth, and vomiting in the infant. This medication has a long half-life of 14 hours. The medication will be most concentrated in the milk at 2-4 hours. Maybe consider a muscle relaxant that we have more data on, or a shorter half-life like Skelaxin (metaxalone) that has a half-life of 3 hours, observe for sedation, vomiting, gastrointestinal upset.[/FONT][/COLOR]


Sandra Lovato R.N.
InfantRisk Center
806-352-2519

[Jenniferll]

Please note: Each and every work may be created to ensure the info supplied by Cerner Multum, Wolters Kluwer Health insurance and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care.