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  • Alemtuzamub and bf

    Alemtuzamub
    Last edited by Lozwo; 05-20-2017, 08:50 AM.

  • #2
    Lozwo,

    Alemtuzamab is rated an L4-no data-possibly hazardous. No data are available on its transfer to human milk, but it is very unlikely to enter milk, due to its large molecular weight. Some caution is recommended, each woman should understand the benefits and risk of using this type of medication in lactation. The half life is 11 hours (1st dose); 6 days (last dose). I would recommend waiting a week to resume breastfeeding if you are concerned.

    The methylprednisonolone is rated an L3-limited data-probably compatible. The amount transferred into breast milk is 0.46-3.15% of your dose. Methylprednisonolone is probably suitable to use during breastfeeding as long as it is taken in low-moderate doses (doses do not exceed 80 mg daily). If high dose pulse therapy is needed (e.g. 1000 mg IV x 3 days), it may be advisable to pump and discard milk for 8-12 hours after each dose.

    Sandra Lovato R.N.
    InfantRisk Center
    806-352-2519




    Last edited by admin; 05-24-2016, 11:38 AM.

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    • #3
      Thank you so much
      Last edited by Lozwo; 05-20-2017, 08:50 AM.

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      • #4
        Oops I mean 2016!

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        • #5
          Lozwo,

          Vaclovir (Valaciclovir or valacyclovir) is rated an L1-limited data-compatible. The amount transferred into breast milk is 4.7% of your dose. Valacyclovir is rapidly metabolized to acyclovir which transfers to human milk. However, the levels in milk are miniscule compared to the clinical doses administered directly to infants. Acyclovr is quite safe for infants with few reported risks or side effects. The risks to a breastfeeding infant would be minimal. Monitor for vomiting and diarrhea.

          As for the alemtuzamab it has a half-life of 6 days after the last dose, it takes approximately 6 half-lives to be completely out so about 36 days to be completely out, but your child is older and not getting as much as milk as a younger infant so a week probably ok.

          Sandra Lovato R.N.
          InfantRisk Center
          806-352-2519

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          • #6
            Thankyou for your replies
            Last edited by Lozwo; 05-20-2017, 08:52 AM.

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            • #7
              Hi there...

              Just wanting to know if you feel there would be concerns around live vaccinations?
              Last edited by Lozwo; 05-20-2017, 08:53 AM.

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              • #8
                Lozwo,

                I spoke with Dr Hale he advised as long as your infant is not severely immunocompromised live vaccines should not be a problem.

                Sandra Lovato R.N.
                InfantRisk Center
                806-352-2519

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                • #9
                  Thank you so much. He isn't as far as far as I knoe
                  Last edited by Lozwo; 05-20-2017, 08:53 AM.

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                  • #10
                    Lozwo,

                    I just spoke with Dr Hale he thinks it is of no risk after 2 weeks post dose. This medication has a large molecular weight and has poor oral bioavailability. At 2 weeks 75% of the medication is already gone.

                    Sandra Lovato R.N.
                    InfantRisk Center
                    806-352-2519

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                    • #11
                      Thank you for your help
                      Last edited by Lozwo; 05-20-2017, 08:54 AM.

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                      • #12
                        Thank you so much

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                        • #13
                          Hi there! Just wanting to know if there is any more information on alemtuzamub and bf?

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                          • #14
                            Lozwo,

                            The information is still the same as above post, no new data.

                            Sandra Lovato R.N.

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                            • #15
                              Thanks Sandra

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