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Ulcerative Colitis and hydrocortisone enema

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  • Ulcerative Colitis and hydrocortisone enema

    I read on the old forum that hydrocortisone enemas were not recommended in high doses while breastfeeding. I was wondering exactly where the cut off was between a high dose and a low dose or if there is no good dosage while nursing. I am flaring while breastfeeding my 10 week old daughter and my GI doctor has recommended a 60ml enema once a day to supplement my other medications until the flare is under control. I would only be taking them for two weeks but that is two weeks too long if it is harming my daughter!

  • #2
    Dear ttrk11,

    We do not have data on how much hydrocortisone transfers into breastmilk.
    Most steroids enter breastmilk in minimal amounts. Hydrocortisone enema has
    a short half-life (time it takes for one-half of the drug to be eliminated) of one to two hours. If you can
    wait three half-lives, which would be between three to six hours after your dose to
    breastfeed, that would decrease the amount of hydrocortisone your infant
    would be exposed to. A short course of two weeks would be of minimal risk
    to your infant. Let me know if you have further questions.

    Cindy Pride, MSN, CPNP
    TTUHSC InfantRisk Center


    • #3
      Thank you so much!