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Long term effects from Zoloft

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  • Long term effects from Zoloft

    With Zoloft being around for so long and babies who were exposed to it while breastfeeding and are now in their 20's with no ill effects developmentally, is it safe to say that long term effects/risks are minimal? I know no long term studies have been done, nor would be able to pin point that Zoloft was the cause of anything, but since we know so many mothers with children who have taken it, wouldn't there be some way of collecting some data or have more reassurance that the medication is safe while nursing?

  • #2
    Honeybear:

    There are hundreds of such papers in PubMed. Check Entrez Pubmed out for more information. Below is one such article.

    Tom Hale Ph.d




    Send to ([url]https://www.ncbi.nlm.nih.gov/pubmed/25589155#[/url])


    Arch Womens Ment Health. ([url]https://www.ncbi.nlm.nih.gov/pubmed/25589155#[/url]) 2015 Apr;18(2):139-46. doi: 10.1007/s00737-015-0499-y. Epub 2015 Jan 15. Sertraline and breastfeeding: review and meta-analysis.


    Abstract


    We examined the risk-benefit profile of sertraline treatment during breastfeeding, summarized the available literature on sertraline use, presented previously unpublished data, and performed a correlation-based meta-analysis of sertraline serum levels in mother-infant pairs. We conducted a search of PubMed and the National Library of Medicine LactMed database. We performed a meta-analysis to examine correlations between maternal and infant serum sertraline levels in the existing literature and in previously unpublished data. Of 167 available infant sertraline levels, 146 (87.4 %) were below the limit of detection, and the meta-analysis found no significant relationship between maternal and infant sertraline concentrations. Of 150 infant desmethylsertraline levels, 105 (70.0 %) were below the limit of detection. The correlation analysis revealed a significant relationship between maternal and infant desmethylsertraline concentrations, but this metabolite has only a fraction of the activity of sertraline. A significant relationship was also found for the sum of sertraline and desmethylsertraline, which stems primarily from the contribution of desmethylsertraline. Sertraline is a first-line drug for breastfeeding women due to documented low levels of exposure in breastfeeding infants and very few adverse events described in case reports. Based on the current literature, neither routine serum sampling nor genotyping is warranted for breastfeeding mothers taking sertraline and/or their infants. Routine pediatric care is appropriate monitoring for breastfed infants of women who take sertraline monotherapy. PMID: 25589155

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    • #3
      So it's safe to say that because of low levels found in infant serum, that any ill long term effects would not be likely?

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      • #4
        Honeybear: Yes, and a healthy mother makes a much healthier infant. We've known for years that depressed mothers have a profound negative impact on the neurobehavioral development of the infant.

        Tom Hale Ph.D.

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        • #5
          What are the ill effects of neurobehavioral development in a depressed mother postpartum and during pregnancy?

          Comment

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