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Submitted by admin on 3 January 2019

I thought this article was interesting in that it suggests that Lithium therapy may be linked to reduced risk of Alzheimer's diseas and stroke.

- Dr. Thomas Hale

Fortschr Neurol Psychiatr. 2018 Dec;86(12):745-753. doi: 10.1055/a-0633-2511. Epub 2018 Nov 12.

[Update - Lithium in the Long-Term Treatment of Bipolar Disorders].

[Article in German; Abstract available in German from the publisher]


Lithium is the gold standard in the long-term treatment of bipolar disorders and the only substance with a convincing antisuicidal effect in affective disorders. Under regular monitoring, lithium represents mostly a well-tolerated and safe medication. Balancing risk and benefits shows that lithium can also be an off-label therapeutic option during pregnancy and breast feeding. Lithium may exhibit neuroprotective effects and has been linked to a reduced risk of Alzheimer's disease and stroke. In the future, biomarkers of lithium response may be available that enable development of more personalized therapies.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID: 30419584

DOI: 10.1055/a-0633-2511