Certolizumab is an interesting IgG molecule, that is used to treat various autoimmune disorders, ulcerative colitis, Crohn's disease. This product is rather unique, in that the transporter piece of the molecule that binds to various transporter receptor sites in humans, was clipped off. Thus certolizumab is not readily transferred via the placenta in the last trimester to the fetus. Its transfer into the milk compartment is blunted as well. This appears to be a good product to use in pregnant and breastfeeding mothers. (Disclaimer: I was involved in the d
The InfantRisk Center gets lots of calls on aspirin, both 81 mg and 325 mg/day doses. We who work in Pediatrics, have for 50 years worried about the risk of Reye syndrome, that occurred many years ago following the use of aspirin in infants and childern while treating fever in viral syndromes. This was an interesting study for us, because we were totally unable to find ANY acetylsalicylic acid in the breastmilk of mothers consuming aspirin.
Montelukast is a commonly used drug in allergies, and as you know, eveyone has allergies. This data shows that levels in milk are really quite low (RID = 0.68) and there is no obvious risk to a breastfeeding infant. TWH
Title: Transfer of Montelukast into Human Milk During Lactation.
Authors: Datta P, Rewers-Felkins K, Baker T, Hale TW.
I always worry about HIGH doses of any drug. We frequently receive calls from mothers undergoing 1000 mg IV doses of methylprednisolone for MS.
Natalizumab is a monoclonal antibody that is only used in humans with multiple sclerosis. It is somewhat toxic, and we were interested to see if this large monoclonal antibody transfers into human milk. Levels in milk appear low, but I made a mistake in the timing of the study, and should have drawn milk levels several mosts longer. I need to redo this study and go out to about 120 days. However, at this point, I still think milk levels are subclinical. TWH
This is one of the InfantRisk Centers studies. We found that levels of linezolid in human milk are really low. Good news if a mom needs this drug. TWH
Title: Transfer of linezolid into breast milk.
Authors: Rowe HE, Felkins K, Cooper SD, Hale TW.
All of us who work in pediatrics know that adequate thyroid function in a newborn is absolutely critical for the infants development. Nothing is worse than hypothyroidism in a newborn infant. While the infant needs low to modest levels of potassium iodine to make all the thyroxin it needs, TOO MUCH iodine basically shuts the infant thyroid down. Remember, there is a pump in the human breast that collects all iodine molecules that pass the mothers breast and transfers that iodine molecule into the milk. This was nature's way to make sure the baby could make
This interesting article confirms what we've suggested for some time, that Zika virus is transferred into human milk. However, should a mom with Zika stop breastfeeding, apparently not, no abnormalities were found in these infants. TWH
Many of us have thought for some time that to avoid cows milk allergy in infants, we could avoid this problem by using the hydrolyzed infant formulas rather than the cows milk formulas. Seems the evidence doesn't support this theory. TWH
This study further confirms what we've thought for some time, that the Warfarin anticoagulant was safe to use in breastfeeding mothers. TWH