First, you must know that doing research with Cannabis products is virtually impossible in the USA today.  The effect of all the governmental legal restrictions, virtually stops all research.  We were most fortunate to find a wonderfully supportive group of lactation consultants and cannabis using moms in Colorado,  who helped us find breastfeeding mothers who were using this product while breastfeeding.  Nine of these moms followed our directions, and provided milk samples.  This is one of the first really accurate assessments of THC transfer into human milk.  W

This drug is a rather unusal compound that is ONLY used thus far for treating  Amyotrophic lateral sclerosis.  I was moved that a patient with ALS called and was continuing to breastfeed her infant, and wanted information about this drug in breastfeeding.  We found that levels of Riluzole were quite low.  Thanks to this heroic mom for providing milk samples during this difficult period of her life.  TWH

 

Certolizumab is an interesting IgG molecule,  that is used to treat various autoimmune disorders, ulcerative colitis, Crohn's disease.   This product is rather unique, in that the transporter piece of the molecule that binds to various transporter receptor sites in humans, was clipped off.  Thus certolizumab is not readily transferred via the placenta in the last trimester to the fetus.  Its transfer into the milk compartment is blunted as well.  This appears to be a good product to use in pregnant and breastfeeding mothers.  (Disclaimer:  I was involved in the d

The InfantRisk Center gets lots of calls on aspirin, both 81 mg and 325 mg/day doses.  We who work in Pediatrics, have for 50 years worried about the risk of Reye syndrome,  that occurred many years ago following the use of aspirin in infants and childern while treating fever in viral syndromes.  This was an interesting study for us, because we were totally unable to find ANY acetylsalicylic acid in the breastmilk of mothers consuming aspirin.

Montelukast is a commonly used drug in allergies,  and as you know, eveyone has allergies.  This data shows that levels in milk are really quite low (RID = 0.68)  and there is no obvious risk to a breastfeeding infant.  TWH

 

Title: Transfer of Montelukast into Human Milk During Lactation.

Authors: Datta P, Rewers-Felkins K, Baker T, Hale TW.

I always worry about HIGH doses of any drug.  We frequently receive calls from mothers undergoing 1000 mg IV doses of methylprednisolone for MS.

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