A new and novel treatment for POSTPARTUM DEPRESSION has just been introduced and is indicated for severe refractory PPD.  Derived from the natural steroid hormone, allopregnanolone, this novel steroid acts directly in the brain to reduce depression.  Its only problem is that it requies a 60 hour IV infusion of drug in a clinical environment.   Studies show it is highly effective.  Again, its indicated for SEVERE refractory PPD.

 

This study suggests that Daily use of HIGH potency cannabis may be associated with higher rates of pyschosis.   Daily users of high potency cannabis were 5 times more likely to encounter Psychosis. 

(My take on this... )  Cannabis has a high attraction for lipid rich adipose (fatty) tissue.  Once filled with daily use of high levels of THC,  plasma levels probably rise signficantly leading to super high levels of THC in brain leading to Psychosis...

 

 

Large study of 1 791 520 Swedish children suggests  fetal exposure to a maternal infection while hospitalized increased the risk for autism and depressionthat.

 

 

JAMA Psychiatry. 2019 Mar 6. doi: 10.1001/jamapsychiatry.2019.0029. [Epub ahead of print]

A new IV drug was just released for the treatment of Postpartum Depression.  Called Brexanolon (Zulresso),  it requires a continuous infusion over 60 hours. 

Brexanolone's mechanism of action is different from that of currently available antidepressants. It is chemically identical to endogenous allopregnanolone, a hormone that decreases after childbirth. Brexanolone acts as a positive allosteric modulator of gammaaminobutyricacidA(GABAA) receptors, which become dysregulated in the postpartum period.

Excellent article that covers the use of anticonvulsants during pregnancy. As expected Valproic acid is the worst and should be avoided.  Folic Acid is greatly beneficial to the fetus.  Not much data on the newer anticonvulsants but many are safer.  Good read.   TWH


While malaria during pregnancy dramatically increases fetal complications,  apparently the drugs might do so as well.  18.5% of exposed pregnancies resulted in miscarriage and 11.8% were elective terminations.    TWH

 

Safety of atovaquone-proguanil during pregnancy.

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