Hello! I should use vaginal suppository which contain 100mg Tinidazole and 150mg Tioconazole 7 days. Should I stop breastfeeding? My baby is 6 months. Now I have stopped but it is very difficult. Many thanks for you help!
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Tinidazole and Tioconazole
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Olga:
About 12.2% of an INTRAVENOUS dose of Tinidazole transfers into human milk. I doubt that the vaginal use would produce levels anywhere close to this since the reported bioavailability is only 10%.
As for Tioconazole, the systemic absorption following vaginal application, is virtually nil ( < 2.9%). I doubt that either of these drugs are a problem when used vaginally for an infant of 6 month. But we don't really have much data, and none on the vaginal use of these drugs.
Tom Hale Ph.D.
Professor
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Originally posted by admin View PostOlga:
About 12.2% of an INTRAVENOUS dose of Tinidazole transfers into human milk. I doubt that the vaginal use would produce levels anywhere close to this since the reported bioavailability is only 10%.
As for Tioconazole, the systemic absorption following vaginal application, is virtually nil ( < 2.9%). I doubt that either of these drugs are a problem when used vaginally for an infant of 6 month. But we don't really have much data, and none on the vaginal use of these drugs.
Tom Hale Ph.D.
Professor
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