Topiramate and Birth Defects

The Food and Drug Administration has announced that use of Topiramate (Topamax) by pregnant women can result in birth defects such as cleft lip or palate.  Topiramate is an anti-convulsant medication used in the treatment of seizure disorder and for the prevention of migraines.  According to recent data, infants exposed to topiramate (as single therapy) during the first trimester of pregnancy have a 1.4% prevalence of oral clefts compared with 0.38 to 0.55% for infants exposed to other anti-seizure medications.  

For more information visit the FDA Website: http://www.fda.gov/Drugs/DrugSafety/ucm245085.htm

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