Methylergonovine and Milk Supply

With respect to milk supply in women taking methylergonovine, we have found that a single post-partum dose will suppress prolactin levels, but doesn't seem to have much of a noticeable effect on supply. Existing studies are conflicted regarding this drug's effect on milk supply if used for more than a single post-partum dose. Some studies found no effect, others describe a very significant drop in milk production which is reversible on stopping the medication.1-4 No new research has been published on this topic in the last 20 years.

James Abbey, MD

References:

1. Del Pozo E, Brun Del Re R, Hinselmann M. Lack of effect of methyl-ergonovine on postpartum lactation. American journal of obstetrics and gynecology. Dec 15 1975;123(8):845-846.

2. Perez-Lopez FR, Delvoye P, Denayer P, L'Hermite M, Roncero MC, Robyn C. Effect of methylergobasine maleate on serum gonadotrophin and prolactin in humans. Acta endocrinologica. Aug 1975;79(4):644-657.

3. Peters F, Lummerich M, Breckwoldt M. Inhibition of prolactin and lactation by methylergometrine hydrogenmaleate. Acta endocrinologica. Jun 1979;91(2):213-216.

4. Weiss G, Klein S, Shenkman L, Kataoka K, Hollander CS. Effect of methylergonovine on puerperal prolactin secretion. Obstetrics and gynecology. Aug 1975;46(2):209-210.

 

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