Hello,
I'm looking for guidance based on the most recent research on Tysabri and pregnancy. What are you seeing on potential risks to fetuses, especially incidences of malformations, when mothers conceive while on Tysabri?
For a little background, I've been on Tysabri for three years; I began the drug due to a very aggressive onset and progression in my disease activity. With my last child, my previous neurologist suggested that I remain on Tysabri until I had a positive pregnancy test. He said that, given the severity of my relapses before Tysabri, he did not want me to go through a washout period. I was told to stop the drug once I was pregnant. I gave birth to a little boy in 2013. He was diagnosed with Post Urethral Valves during the pregnancy, and he was born in renal failure. He died at 8 days old. My previous neurologist, antenatal, and neonatal doctors do not think that my son's problems were caused by the Tysabri.
I am now considering trying for another child, and I have no idea what we should do regarding my Tysabri usage. My current neurologist (with whom I do not have a good doctor-patient relationship) is very insistent that I come off of Tysabri at least 3 months prior to TTC, although current research coming out of the Tysabri Pregnancy Exposure Registry suggests no increased risks for babies conceived on the drug.
I am scared to conceive on the drug, given my boy's malformation, but I am also afraid to go through a washout period, during which I might have another major relapse and not be able to have a child at all.
Any information is appreciated.
I'm looking for guidance based on the most recent research on Tysabri and pregnancy. What are you seeing on potential risks to fetuses, especially incidences of malformations, when mothers conceive while on Tysabri?
For a little background, I've been on Tysabri for three years; I began the drug due to a very aggressive onset and progression in my disease activity. With my last child, my previous neurologist suggested that I remain on Tysabri until I had a positive pregnancy test. He said that, given the severity of my relapses before Tysabri, he did not want me to go through a washout period. I was told to stop the drug once I was pregnant. I gave birth to a little boy in 2013. He was diagnosed with Post Urethral Valves during the pregnancy, and he was born in renal failure. He died at 8 days old. My previous neurologist, antenatal, and neonatal doctors do not think that my son's problems were caused by the Tysabri.
I am now considering trying for another child, and I have no idea what we should do regarding my Tysabri usage. My current neurologist (with whom I do not have a good doctor-patient relationship) is very insistent that I come off of Tysabri at least 3 months prior to TTC, although current research coming out of the Tysabri Pregnancy Exposure Registry suggests no increased risks for babies conceived on the drug.
I am scared to conceive on the drug, given my boy's malformation, but I am also afraid to go through a washout period, during which I might have another major relapse and not be able to have a child at all.
Any information is appreciated.
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