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IVF medication

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  • #1

    IVF medication

    Hi, I'm starting an IVF cycle - Frozen Embryo Replacement - so am on reduced meds compared to a fresh cycle. But I am wondering can you advise as to the safety of the meds I will be taking for my 18 month old daughter who currently nurses once a day, in the morning.

    My protocol consists of:

    Oestradiol Valerate (Progynova) 2mg x 3 times daily
    Low Dose Aspirin 75mg daily until Embryo Replacement
    Intravenous Intralipid 20% solution on Day 8
    Prednisolone 10mg daily, rising to 20mg daily after Embryo Replacement
    Utrogestan 400mg x 2 times daily
    Clexane 20mg once daily after Embryo Replacement

    Thanks so much for any advice you can give.
    Tags: None
  • #2
    Dear Katie,

    Estrogen (Oestradiol) and progesterone (Utrogestan) have the potential to decrease milk supply but since your infant is not dependent on your milk supply for nutrition, these medications are compatible with breastfeeding in your case. Aspirin in regular doses is not recommended during breastfeeding due to the risk of Reyes syndrome if your child becomes ill with a viral illness. Since you are on a low dose, however, the risk to your child is minimal especially since your child ingests a much smaller volume of breastmilk compared to infants up to 6 months of age. Prednisolone is a steroid. Doses higher than 40 mg per day for extended periods are not recommended due to risk of decreased bone growth. Since you are on a low dose for a short period of time the risk to your child is minimal. If you have concerns, you can have your pediatrician monitor your child's growth. Intralipids are just fats so there is no contraindication during breastfeeding. Clexane is not orally bioavailable which means even if it was in your breastmilk, your child wouldn't be able to absorb it. The drug is given as an injection not a pill for that reason. In summary, the risk to your child with your iVF medications is minimal. Hope this information is helpful.

    Sincerely,
    Cindy Pride, MSN, CPNP
    TTUHSC InfantRisk Center
    Last edited by cpride; 09-13-2012, 11:23 AM.

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    • #3
      That's fantastic news, thank you! I'm delighted to be able to continue breastfeeding and not worry that I'm exposing my daughter to any risk. I'm planning on not feeding her for a while following embryo replacement to avoid the risk of uterine contractions ... and hoping my daughter doesn't lose the knack of how to BF in the interim... I would really love to continue breastfeeding her but have to balance her need to nurse with the overall benefit to her of a younger sibling.
      Thank you so much for the information. It is helpful and reassuring.

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