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Hydroxyurea for sickle cell anemia

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  • #1

    Hydroxyurea for sickle cell anemia

    Does anyone have any information on hydroxyurea and breastfeeding? Hale (2008) says L2 ("Safer") but it seems everywhere else I look says it's contraindicated. This would be for daily use. Any insight would be appreciated.

    Thanks!
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  • #2
    Dear Piedmontbabies,

    Hydroxyurea, an antineoplastic agent, is now categorized as L3. The amount of the mom's dose that is secreted into breastmilk (RID) is 4.3 %. The half-life (how long it takes for half of the drug to be excreted from the body) is short at 3 to 4 hours. Due to the potential toxicity of the drug, even though the RID is low, it is recommended to withhold breastfeeding for a minimum of 12 to 24 hours after the dose. Please call the InfantRisk Center at 806-352-2519. We are open Monday through Friday 8 to 5 CST. Because you will be taking the medication daily, we need to get a little more information on your dose, the age of your child etc. to give specific recommendations for your particular situation.

    Sincerely,
    Cindy Pride, MSN, CPNP
    TTUHSC InfantRisk Center

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    • #3
      Thanks!

      Thank you for getting back to me. This is not for me, so I passed your phone number on to the mom who will be taking the medication.

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