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I did not find any information on these two meds in Dr. Hale's latest edition. A mother is being treated for Alpha 2-Antiplasmin Deficiency. Is there any information available?
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Snyderj:
Tranexamic acid is excreted into human milk and is present in the mother's milk at a concentration of about one hundredth of the corresponding serum concentrations. In one study, it was determined that after a 2 day treatment of tranexamic acid in lactating women, the milk concentration was approximately 1% of the peak serum concentration. The effects on an infant receiving a small amount of tranexamic acid is not known.
Aminocaproic acid is an antifibrinolytic agent used in prevention of bleeding with cardiac surgery, bleeding disorders, or in patients who are currently on anticoagulant therapies. It also prevents spontaneous fibrinolysis. There are no data on its transfer into human milk. If we were to assume a 1 to 1 milk/plasma ratio (which is probably high), and a normal maternal therapeutic plasma range of 130 µg/mL, then milk levels would be 130 µg/mL and with a relative infant dose of 19%. While high, this is very unlikely. Use caution. Observe the infant closely during therapy.
Tom Hale Ph.D.
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